Reserve concomitant prescribing of such drugs in patients for whom other treatment choices are inadequate. Limit dosages and durations into the least required. Check intently for signs of respiratory depression and sedation.buprenorphine buccal decreases effects of hydrocodone by pharmacodynamic antagonism. Steer clear of or Use Alternate Drug. Mix

Agitation back, leg, or stomach pains black, tarry stools bleeding gums blistering, peeling, or loosening from the skin blood while in the urine or stools blood in vomit bluish lips or pores and skin chest tightness chills choking confusion cough darkish urine darkening from the pores and skin lower within the frequency of urination reduce in urine